Polyclonal Antibody to DTX1

Researchers have indicated that they want access to novel target antibodies quickly to aid in their research. IMGENEX is therefore pleased to be able to offer researchers access to products that are not fully characterized or validated. IMGENEX IMX antibodies are shown by Peptide ELISA to bind to the peptide used as immunogen. Investigators should empirically determine the suitability of the antibody, including optimal dilutions, for other applications of interest.

• We cannot guarantee that the IMX antibody will work in any application other than in a Peptide ELISA against the peptide used as immunogen and therefore can not offer a refund if the antibody does not work in your application.

• IMX antibodies are offered at a lower price compared to more highly validated antibodies.

• We are not able to provide the peptide used as immunogen for IMX antibodies.

As IMX antibodies are not fully validated we appreciate your feedback. Customer feedback is used to help generate testing methodologies which can lead to further product validation or withdrawal.

Protein deltex-1 is a Notch Signaling Pathway protein which belongs to the Deltex Family of proteins. It contains one RING-type zinc finger and two WWE domains. DTX1 acts as regulator of Notch signaling and has functional significance in cell-fate determinations. It mediates the antineural activity of Notch by inhibiting the transcriptional activation mediated by MATCH1. It is involved in neurogenesis, lymphogenesis, myogenesis and MZB (Marginal Zone B) cell differentiation. It promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. It functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. DTX1, along with DTX2 and DTX3, functions as E3 ligases based on their capacity for self ubiquitination.

Antigen
Amino acids 583-599 KTEFGSNLTGHGYPDAS of human DTX1 protein were used as the immunogen.